Substrate Plasma VII

Substrate Plasma VII, Factor VII Deficient (Substrate Plasma VII) according to TU 9398-044-05595541-2012. The kit is designed for determining the activity of blood coagulation Factor VII (Factor VII) in the plasma of patients and Factor VII preparations using a one-stage clotting method. It can be used manually, as well as on all types of automatic and semi-automatic coagulometers.

The activity of coagulation Factor VII in patient plasma is determined in the following cases: • Diagnosing deficiencies in factors due to hereditary or acquired conditions; • Monitoring therapy with the administration of prothrombin complex preparations; • Detailed monitoring during oral anticoagulant therapy; • Assessing liver function in various pathologies.

Principle of the Method: Upon adding Factor VII-deficient substrate plasma to the diluted test plasma, correction of all coagulation factors occurs except for Factor VII. Therefore, the clotting time in the prothrombin time test of the mixture of diluted test plasma and substrate plasma deficient in Factor VII depends only on the activity of Factor VII in the test plasma. The activity of Factor VII is determined using a calibration curve of dilutions of the calibrator plasma with a known activity of Factor VII.