КМ-14
Registration CertificateSubstrate plasma, deficient in factor XI (Substrate Plasma XI) according to TU 9398-042-05595541-2012. The kit is intended for determining the coagulation factor XI (F XI) activity in the blood plasma of patients and fresh-frozen donor plasma (FFDP) using a one-stage clotting method. It can be used for manual methods as well as on all types of automatic and semi-automatic coagulometers.
The determination of factor XI activity is carried out to investigate the cause of prolonged activated partial thromboplastin time, diagnose deficits in factors due to inherited or acquired conditions, and differentiate between dysproteinemia and the synthesis of inactive coagulation factors.
Principle of the method: Upon addition to the diluted test plasma, the substrate-deficient plasma corrects all coagulation factors except factor XI. Therefore, the clotting time in the APTT test of the mixture of the diluted test and substrate-deficient plasma for factor XI depends solely on the activity of factor XI in the test plasma. The activity of factor XI is determined using a calibration graph of dilutions of the calibrator plasma with established factor XI activity.
Composition:
Interpretation of results: In the normal plasma of healthy individuals, the activity of factor XI is 70 — 120% of the norm. The activity of coagulation factor XI in the plasma of patients is determined in the following cases:
Normal and pathological values of factor XI activity should be monitored using Control Plasma, code KM-2.
