Plasma substrate XII

Plasma substrate, deficient in factor XII (Plasma substrate XII) according to TU 9398-043-05595541-2012. The kit is intended for determining the coagulation activity of blood plasma in patients and fresh-frozen donor plasma (FFDP) using a one-stage clotting method.

For manual methods, as well as for all types of automatic and semi-automatic coagulometers.

Method Principle: When added to the diluted test plasma, substrate-deficient plasma corrects all coagulation factors except for factor XII. Therefore, the clotting time in the activated partial thromboplastin time (APTT) test of the mixture of diluted test and substrate-deficient plasma for factor XII depends solely on the activity of factor XII in the test plasma. Factor XII activity is determined using a calibration graph of dilutions of calibrator plasma with established factor XII activity.