Reagent kit for fibrinogen determination (Fibrinogen Test) according to TU 21.20.23-068-05595541-2020 is designed for determining the concentration of fibrinogen in blood plasma using the clotting method according to Clauss on all types of semi-automatic and automatic coagulometers.
The determination of fibrinogen content in human blood plasma is one of the main tests in hemostasis research. The test is intended for measuring fibrinogen content in cases of hyperfibrinogenemia, which is associated with the severity of inflammatory, immune, and destructive processes. It is also a factor in the increased risk of developing hyper-viscous syndrome, arterial thrombosis, organ infarctions, as well as in acute disseminated intravascular coagulation (DIC) syndrome, and in the treatment with fibrinolytics, in congenital hypo- and dysfibrinogenemia.
Method Principle: The clotting time of diluted 10 times citrated blood plasma is measured upon the addition of an excess of thrombin. In this system, the fibrinogen concentration in plasma determines the time of fibrin clot formation, which is measured using a calibration graph of dilutions of plasma-calibrator with established fibrinogen content.
Composition of kit PG-10/1:
One kit is intended for conducting 320 analyses with a consumption of 0.05 ml of thrombin per analysis.
Composition of kit PG-10/3:
One kit is intended for conducting 800 analyses. Normal and pathological values of fibrinogen should be monitored using Control Plasma (pool of healthy donors) (Plasma N), code KM-1.
